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KMID : 0377619650080050521
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Korean Jungang Medical Journal
1965 Volume.8 No. 5 p.521 ~ p.531
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STUDIES ON THE IMMUNIZATION THROUGH VAGINA
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Abstract
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In order to know the effect of antigenic substances introduced into the vagina on the antibody production, heat-extracted antigen of Shigella flexneri la ox serum, and homologous and heterologous semen were socked in cotton ball and repeatedly impregnated into the vagina of rabbits, and antibodies in serum and vaginal washing were pursued by means of precipitation, hemagglutination and agglutination techniques. The effect of cortisone, sex hormones and antibiotics on the antibody production was also studied and the following results were obtained.
1. Precipitating, hemagglutinating and agglutinating antibodies against Sh. flexneri la antigen and ox serum were produced in sera of rabbits when antigens were repeatedly impregnated in vagina. Antibody titers were higher in pregnant rabbits than in non-pregnant.
2. Cortisone administered subcutaneously during the vaginal impregnation of antigen inhibited completely the antibody production in sera, and almost completely the antibody production by subcutaneous immunization. Testosterone and estrogen slightly enhanced the effect of vaginal immunization, but not that of sub-cutaneous immunization. Large amounts of penicillin, streptomycin and aureomycin showed inhibitory effect against vaginal as well as subcutaneous immunization.
3. Cortisone, sex hormone and antibiotics administered before or beginning of the immunization expressed only minor effect in the beginning of immunization. The effect of these substances was also observed in the booster immunization.
4. Semen of rabbit introduced in vagina of rabbit did not show any antigenic effect, but semen of guinea pig repeatedly introduced in vagina of rabbit showed antibody production in only small amount.
5. Tn the course of vaginal immunization, antibody was only weakly determined by hemagglutination in vaginal washing.
6. Antibody production in sera of rabbit was very poor when antigenic substances were inpregnated in vagina of rabbits whose portio uteri were ligated to cut out the communcation between uteri and vagina.
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